A Community-Based Trial on The Comparison of Efficacy, Safety and Cost Effectiveness of Ferrous Sulphate and Ferrous Ascorbate for Anaemia in Pregnancy In Madhya Pradesh, India

Background: Anaemia has significant impact on health of the fetus as well as that of mother. Increased need of iron during pregnancy especially after 2nd trimester makes iron supplementation mandatory. Ferrous ascorbate is known to exist intact inside the gastrointestinal tract due to the stable chelation of iron with ascorbate. This compound does not dissociate due to any of the food inhibitors. The aim is to study the effec-tiveness of Ferrous Ascorbate and Ferrous sulphate in terms of compliance and cost effectiveness of manage-ment of anaemia in pregnancy. Methodology: Study design: Quasi Experimental study, Study area: District Vidisha, Study participants: Preg-nant women of first trimester registered during the study period in the selected Anganwadis/ Gram Arogya Kendra (GAK), Sample size: 240 antenatal mothers. Results: Baseline mean haemoglobin was 11.31±1.05 gm/dl. The mean increase in Ferrous Sulphate was 0.55 gm/dl, and in Ferrous ascorbate was 1.27 gm/dl. Ferrous Sulphate was less compliant than Ferrous ascorbate, and has higher efficacy and lesser side effects. Only Rs. 10.2 additional cost per antenatal mothers for increase of ≥1gm% in Hb will be borne by government if Ferrous Sulphate is replaced by Ferrous Ascorbate. Conclusions: Study results show statistically significant difference in rise of haemoglobin amongst the ante-natal mothers consuming Ferrous ascorbate over Ferrous Sulphate

A Study Of Solanaceae Family Of Homoeopathic Materia Medica

Background:One of the best method ofobtaining an idea of the action of any drug is to Study from the Source of the drug, its habitat, how it exists and acts in nature and what does that says for the type of symptoms and type of person that it will help to cure..Objectives:1.To Study the nfeatures of Solanaceae family.2.To determine their utility in clinical Practice. 3.To utilize the above understanding for helping mankind in enjoying a healthy life, free from disease manifestations on mental and physical level. Material & Method:Study of Homoeopathic medicines in Solanaceae in Materia Medica point of view and also through case study after definining, analyzing then further testing data for accuracy.Purposive Sampling for research purpose will be done. Selection of the medicine will be according to concept of individualization. Result:Observed results will be discussed on study of cases in which the efficacy of the Solanacae in various disease conditions shall be present positive and negative points and compare, with the findings in theliterature.Conclusion:Understanding of Solanaceae family from dimensions of Materia Medica, natural habitat helps to understand totality of group and thereby making our knowledge of Materia Medica more complete and precise.

Epidemiology of sickle cell disease in a rural hospital of central India.

OBJECTIVE: To study the epidemiology of sickle cell disease in pediatric age group in a rural hospital of Central India. DESIGN: Prospective descriptive hospital based study. SUBJECTS: 99 admitted patients of sickle cell disease were studied for a period of 1 year. RESULTS: Prevalence of sickle cell disease was 5.7% (99/1753) hospitalizations of which 61.6% (n=61) had homozygous sickle cell disease (HbSS) whereas 38.4% (n=38) had heterozygous state (HbAS). Of these, 62 (63%) were below five years of age. Male : Female ratio was 1.65:1 in HbSS cases and 1.71:1 in HbAS cases. History of consanguinity was present in 7 (7%) of which 5 (8.2%) had HbSS and 2 (5.2%) had HbAS. Incidence was maximum in the Mahar community (70%) followed by Kunbi (8 %) and Teli (6%). Vascular occlusive crisis (23. 3%) was the commonest crisis encountered followed by hyperhemolytic crisis (16.3%). There was no correlation between hemoglobin levels and the occurrence of vascular occlusive crisis. Maximum cases required their first blood transfusion between second and third year of age. Requirement of blod transfusion was more in HbSS cases. Four patients died of which three had HbSS and were below five years of age. Splenic sequestration crisis was the commonest cause of death. CONCLUSION: Sickle cell disease is prevalent in this area and most cases present before 5 year of age. VOC is the commonest crisis seen, but death often occurs due to sequestration crisis and usually below 5 years of age.

Massive lower gastrointestinal bleeding from cecal lymphoid polyp in renal transplant recipient.

A 25-year-old renal transplant recipient receiving anticoagulant therapy for renal vein thrombosis, presented with massive lower gastrointestinal bleeding. Superior mesenteric angiogram revealed active bleeding in the cecum. Colonoscopy revealed a sessile ulcerated polyp in the cecum with satellite polyps. The polyps were fulgurated with Nd:YAG laser. Colonoscopy later revealed a remnant of the polyp, which was excised. The histopathology revealed a lymphoid polyp.

HIV-1 seropositivity in pulmonary tuberculosis (study of 340 cases from Marathwada).

An investigative study was carried out in 340 cases of established pulmonary and presumed pleural tuberculosis for co-occurrence of HIV-1 infection in them. Confirmatory screening for HIV-1 was carried out with both ELISA (Vironostika) and Serodia commercial kits in all reactive samples on first screening. In all, 16 cases proved to be having HIV-1 coexistent infection with pulmonary tuberculosis. Their preliminary vital clinical observations and roentogenic finding are summarized and literature reviewed briefly.

Chylothorax--a conservative approach (a case report).

Lymphatic blockage due to a non-specific inflammation probably of a filarial origin caused dilatation and ectasia of lymph channels at thoracic inlet of a child. Transudation of lymph through these channels led to chylothorax. The present case report highlights the significance of conservative approach towards this complex problem.